Pathology ·
Foundation models subtype Barrett's esophagus slides; Lunit AI and pathologists agree on 73% of PD-L1 scores; Raman histology aids pituitary surgery
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Ensembled histopathology foundation models subtyped Barrett's esophagus and detected adenocarcinoma on 3,528 whole-slide images in an npj Digital Medicine study. Lunit reported company data on AI and pathologist agreement in PD-L1 scoring of lung cancer, and stimulated Raman histology was compared with conventional hematoxylin and eosin staining during pituitary tumor surgery.
THE DETAILS
- AI Oct 21, 2026In a study published Oct. 21 in npj Digital Medicine, ensembled histopathology foundation models were applied to 3,528 hematoxylin and eosin-stained whole-slide images from 790 patients with Barrett's esophagus. For morphological subtyping, the ensemble reached an area under the receiver operating characteristic curve (AUROC) of 0.907 with a kappa of 0.651; for esophageal adenocarcinoma detection, AUROC was 0.909 with a kappa of 0.673. The authors cited persistent challenges in dysplasia assessment and the need for external validation.Sources: npj Digital Medicine, PubMed
- AI Oct 20, 2026Lunit said Oct. 20 that in a Japanese study of 993 patients with surgically resected non-small cell lung cancer, PD-L1 tumor proportion scores from its Lunit SCOPE PD-L1 AI and from pathologists had an overall concordance rate of 73% (kappa 0.58). Of 211 tumors scored below 1% by the pathologist but 1% or higher by the AI, the AI classified 204 (97%) as low expression of 1% to 10%. The company-reported results are set for a poster at the European Society for Medical Oncology Congress on Oct. 25; Lunit SCOPE products are for research use only.Sources: Lunit (PR Newswire), Medical Device Network
- Technology Oct 23, 2026In a study published Oct. 23 in the Journal of Neurosurgery, stimulated Raman histology was used for near real-time intraoperative assessment of pituitary neuroendocrine tumors during endoscopic transsphenoidal surgery in 28 patients, yielding 66 tissue samples. Comparability with conventional hematoxylin and eosin (H&E) staining was excellent in 37 samples (56.1%), good in 20 (30.3%) and low in nine (13.6%). The authors said the findings support the technique as a useful aid to intraoperative decision-making in pituitary surgery.Sources: Journal of Neurosurgery, PubMed
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